Dr. Mark's research has focused on the role of the sympathetic nervous system in physiologic and pathologic states. After a sabbatical in Uppsala, Sweden in 1983-84, Dr. Mark introduced the microneurographic method for direct intraneural recordings of sympathetic nerve activity into the US and, with his trainees, employed this method to advance understanding of human autonomic control in exercise, heart failure, hypertension, sodium intake and obesity.
His current research addresses mechanisms of obesity-induced hypertension, including the sympathetic actions of leptin and the concept of selective leptin resistance in obese states. With Dr. Robin Davisson at Weill Cornell Medical College, his research from 2009-2015 focused on the role of endoplasmic reticulum stress in the subfornical organ in obesity and angiotensin induced hypertension in mouse models of obesity and hypertension.
Deletion of p22phox-dependent oxidative stress in the hypothalamus protects against obesity by modulating β3-adrenergic mechanisms.
Lob HE, Song J, Hurr C, Chung A, Young CN, Mark AL, Davisson RL.
JCI Insight. 2017 Jan 26;2(2):e87094. doi: 10.1172/jci.insight.87094.
Obesity, Hypoxemia, and Hypertension: Mechanistic Insights and Therapeutic Implications.
Mark AL, Somers VK.
Hypertension. 2016 Jul;68(1):24-6. doi: 10.1161/HYPERTENSIONAHA.116.07338. Epub 2016 May 9.
Angiotensin type 1a receptors in the forebrain subfornical organ facilitate leptin-induced weight loss through brown adipose tissue thermogenesis.
Young CN, Morgan DA, Butler SD, Rahmouni K, Gurley SB, Coffman TM, Mark AL, Davisson RL.
Mol Metab. 2015 Jan 31;4(4):337-43. doi: 10.1016/j.molmet.2015.01.007. eCollection 2015 Apr.
Selective leptin resistance revisited.
Am J Physiol Regul Integr Comp Physiol. 2013 Sep 15;305(6):R566-81. doi: 10.1152/ajpregu.00180.2013. Epub 2013 Jul 24. Review.
DiBona GF, Mark AL.
Hypertension. 2013 Jan;61(1):4
Angiotensin type 1a receptors in the subfornical organ are required for deoxycorticosterone acetate-salt hypertension.
Hilzendeger AM, Cassell MD, Davis DR, Stauss HM, Mark AL, Grobe JL, Sigmund CD.
Hypertension. 2013 Mar;61(3):716-22. doi: 10.1161/HYPERTENSIONAHA.111.00356. Epub 2012 Dec 24.
A brain leptin-renin angiotensin system interaction in the regulation of sympathetic nerve activity.
Hilzendeger AM, Morgan DA, Brooks L, Dellsperger D, Liu X, Grobe JL, Rahmouni K, Sigmund CD, Mark AL.
Am J Physiol Heart Circ Physiol. 2012 Jul 15;303(2):H197-206. doi: 10.1152/ajpheart.00974.2011. Epub 2012 May 18.